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STUDY 2015 HTM file
Opioid treatment at release from jail using extended-release naltrexone: a pilot proof-of-concept randomized effectiveness trial
Though few seemed willing to try this treatment, among those who did, opiate-blocking injections active for about a month helped formerly dependent prisoners in New York City’s jail avoid relapse to regular opiate use after release.
STUDY 2017 HTM file
Effectiveness of injectable extended-release naltrexone vs daily buprenorphine–naloxone for opioid dependence: A randomized clinical noninferiority trial
Can monthly injections of extended-release naltrexone be considered on a par with the standard daily opioid substitute in Norway for people wanting to maintain abstinence from heroin?
STUDY 2016 HTM file
Extended-release naltrexone to prevent opioid relapse in criminal justice offenders
Added to basic counselling alone, monthly injections of the opioid-blocking drug naltrexone helped prevent relapse among US offenders with a history of opioid dependence recently released from prison or under criminal justice supervision in the community – findings most applicable to those who prefer opioid-free to opioid-maintenance treatments.
STUDY 2001 PDF file 763Kb
Disulfiram treatment of alcoholism
A reminder of the landmark study which galvanised researcher to investigate how disulfiram can be made to work and pioneered methodologies capable of delivering clinically useful answers. Expert commentary plus the reflections of the original researcher.
STUDY 2010 HTM file
Disulfiram in severe alcoholism – an open controlled study
From Denmark a randomised trial of disulfiram in the treatment of alcohol dependence reveals the major weakness of the treatment - that among some sets of patients, few will consistently take tablets they know will cause unpleasant effects if they drink.
REVIEW 2011 HTM file
The efficacy of disulfiram for the treatment of alcohol use disorder
Given effective supervision from family or clinicians to help ensure patients keep taking the tablets, this first systematic synthesis of research finds that on average the drug disulfiram, which produces an unpleasant physical reaction to drinking, does act as an aid to abstinence in the treatment of alcohol dependence.
STUDY 1966 HTM file
Treatment of skid-row alcoholics with disulfiram
In the early ’60s in Atlanta in the USA, a pioneering trial tested whether faced with the alternative of another spell in jail, ‘skid-row’ repeat drunkenness offenders would take a drug which generates deterrent reactions to alcohol. Most did, belying their supposedly hopeless condition.
STUDY 1992 HTM file
Disulfiram treatment of alcoholism
Still relevant today, from the early 1990s a UK randomised trial of disulfiram in the treatment of alcohol dependence found that it significantly reduced drinking when there was daily supervision to make sure patients took the tablets, and they knew these would cause unpleasant physical effects if they drank.
STUDY 2001 PDF file 99Kb
Naltrexone prevents return to heavy drinking
The British study which provided the largest test to date of naltrexone in the treatment of alcohol dependence. In conditions typical of NHS alcohol treatment centres, it confirmed that taken as directed, the drug reduces alcohol consumption.
STUDY 2001 PDF file 143Kb
In UK acamprosate fails to prevent relapse to drinking but European evidence remains positive
A large UK trial found that acamprosate failed to reduce relapse among detoxified alcoholics but more positive international evidence was confirmed in Italy. Differences in patients, regimes and measures might account for the difference.
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