Estimation of life expectancy and the expected years of life lost among heroin users in the era of opioid substitution treatment (OST) in Taiwan
Effectiveness bank home page. Opens new windowResearch abstract

This entry is for a study added to the Effectiveness Bank but not fully analysed. Usually the entry consists only of the reference and an edited version of the original abstract, with either no commentary from Drug and Alcohol Findings or only essential points. The original study was not published by Findings; click Title to order a copy. Free reprints may be available from the authors – click prepared e-mail.

Links to other documents. Hover over for notes. Click to highlight passage referred to. Unfold extra text Unfold supplementary text
Copy title and link | Comment/query |

Estimation of life expectancy and the expected years of life lost among heroin users in the era of opioid substitution treatment (OST) in Taiwan.

Chang K.C., Lu T.H., Lee K.Y. et al.
Drug and Alcohol Dependence: 2015, 153, p. 152–158.
Unable to obtain a copy by clicking title? Try asking the author for a reprint by adapting this prepared e-mail or by writing to Dr Wang at

After adjusting for other influences, heroin users diagnosed as dependent at a psychiatric centre in Taiwan who started opioid substitution treatment lived nearly eight years longer than those who did not enter treatment. However, the treated group were more likely to commit suicide, usually associated with a history of depression.

Summary Opioid substitution treatment including methadone and buprenorphine maintenance has been implemented in Taiwan since 2006. This study aimed to estimate the life expectancy and expected years of life lost among heroin users who were versus were not engaged in this treatment.

The details of 1283 heroin users diagnosed as opioid dependent at a psychiatric centre from 2006 to 2008 were linked to Taiwan’s National Mortality Registry until the end of 2011. Among them, 983 went on to start opioid substitution treatment at the centre’s clinics, while 300 did not. Survival rates were calculated and extrapolated to 50 years from diagnosis to estimate average life expectancy in both sets of heroin users. Then expected years of life lost for both sets were estimated by subtracting their life expectancies from those of people in the general population of similar age and sex. Standardised mortality ratios were calculated as the observed number of deaths among the heroin users divided by the expected number of deaths, calculated on the basis of how many people in the Taiwan general population of similar age and sex died (or died from the same causes) in the same years.

After extrapolation to 50 years, for heroin users who entered substitution treatment estimated average life expectancy from the time of diagnosis at the centre was 27.4 years, and expected years of life lost compared to the general population, 10.6 years. Corresponding figures for those who did not enter treatment were 20.2 and 18.4 years. Per 1000 person-years, death rates from all causes during 2006 to 2011 for the treatment and non-treatment groups of heroin users were 15.5 and 23.9 respectively, 7.5 times and about 10 times the rate among matched people in the general population. But for deaths due to suicide in particular, in the treatment group (among whom most of the deceased had been treated for depression) death rates were 16 times greater than among matched people in the general population, but only 3 times greater in the non-treatment group.

The authors concluded that among heroin users who were diagnosed at the psychiatric centre, entering opioid substitution treatment saved 7.8 years of life more than not entering treatment. Effective suicide prevention programmes could enhance the treatment’s life-saving effect, especially among patients also suffering depressive disorders.

Last revised 23 July 2015. First uploaded 23 July 2015

Open Effectiveness Bank home page

Top 10 most closely related documents on this site. For more try a subject or free text search

STUDY 2010 Risk of death during and after opiate substitution treatment in primary care: prospective observational study in UK

STUDY 2020 Comparative effectiveness of different treatment pathways for opioid use disorder

REVIEW 2010 A review of opioid dependence treatment: pharmacological and psychosocial interventions to treat opioid addiction

STUDY 2015 Impact of treatment for opioid dependence on fatal drug-related poisoning: a national cohort study in England

STUDY 2018 The impact of buprenorphine and methadone on mortality: a primary care cohort study in the United Kingdom

STUDY 2004 Opiate antagonist treatment risks overdose

STUDY 2010 Were the changes to Sweden’s maintenance treatment policy 2000–06 related to changes in opiate-related mortality and morbidity?

DOCUMENT 2014 Time limiting opioid substitution therapy

DOCUMENT 2017 Drug misuse and dependence: UK guidelines on clinical management

STUDY 2008 Mortality prior to, during, and after opioid maintenance treatment (OMT): a national prospective cross-registry study