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Dhital R., Norman I., Whittlesea C. et al.
Addiction: 2015, 110(10), p. 1586–1594.
Despite a clear rationale for embedding brief interventions in community pharmacies, this UK trial found no evidence that they would reduce hazardous or harmful drinking.
Pierce M., Bird S.M., Hickman M. et al.
Addiction: 2015, 111, p. 298–308.
Implication of this English study is that to save the lives of people dependent on heroin or similar drugs, they should be engaged and retained in substitute prescribing programmes like methadone maintenance until there is little risk of their relapsing after leaving. Shortly after leaving residential/inpatient settings was the highest risk period.
White M., Burton R., Darke S. et al.
Addiction: 2015, 110, p. 1321–1329
First robust analysis estimates that between 2008 and 2011, 880 opioid-related ‘overdose’ deaths were prevented each year by addiction treatment in England, reducing total deaths by over 40%.
Mahu I.T., Doucet C., O’Leary-Barrett M. et al.
Addiction: 2015, 110, p. 1625–1633.
School staff trained to deliver personality-targeted substance use interventions to London high school pupils – effectively delaying cannabis use among a subset (those identified as ‘sensation-seekers’).
Benishek L.A., Dugosh K.L., Kirby K.C. et al.
Addiction: 2014, 109(9), p. 1426–1436.
Systematically giving substance use patients a chance to win valuable prizes if they test abstinent offers a lower-cost alternative to ‘contingency management’ systems which provide rewards each time, but does it work? Across 18 studies the answer was ‘Yes,’ though effects soon faded.
Williams E.C., Rubinsky A.D., Chavez L.J. et al.
Addiction: 2014, 109(9), p. 1472–1481.
Evaluated across an entire region, a determined effort to implement alcohol screening and brief intervention in the US health system for ex-military personnel led to no significant reductions in drinking – results seen as a prime example of the disappointing impacts of alcohol brief interventions in real-world conditions.
STUDY 2014 HTM file
Treatment retention, drug use and social functioning outcomes in those receiving 3 months versus 1 month of supervised opioid maintenance treatment. Results from the Super C randomized controlled trial
Holland R, Maskrey V., Swift L. et al.
Addiction: 2014, 109(4), p. 596–607.
A randomised trial conducted in England found that the (at the time) recommended three months of supervised consumption of prescribed opioid substitutes like methadone conferred no significant advantages over supervising only for up to the first four weeks of treatment, but the findings applied only to the minority of patients for whom random allocation was thought feasible and safe.
Maisel N.C., Blodgett J.C., Wilbourne P.L. et al.
Addiction: 2013, 108(2), p. 275–293.
Naltrexone and acamprosate both modestly curtail drinking among alcohol-dependent patients, but which is best in which circumstances and for which treatment goals? To find out this review compared the medications’ performance when separately benchmarked against a placebo, bringing to bear much more data than is available from the few trials which directly compared the two drugs.
Vickerman P., Martin N., Turner K. et al.
Addiction: 2012, 107, p. 1984–1995.
Among the messages of this simulation model for the UK and other countries is the resilience of hepatitis C in the face of considerable investment in methadone and needle exchange services, that these have nevertheless helped and need to be maintained and if possible expanded, but also that further measures are required to substantially curtail the virus.
Ling W., Shoptaw S., Hillhouse M. et al.
Addiction: 2012, 107(2), p. 361–369.
The US company which owns and markets the controversial PROMETA proprietary combination of drugs for methamphetamine dependence funded a rigorous trial by independent researchers; the result was a no-better-than-placebo verdict, another negative in the search for drugs to counter stimulant dependence.
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