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REVIEW 2015 HTM file
Heroin on trial: systematic review and meta-analysis of randomised trials of diamorphine-prescribing as treatment for refractory heroin addiction
The UK has a long history of prescribing heroin for the treatment of heroin dependence. What has research from six countries concluded about this intensive intervention intended for patients who would otherwise be considered ‘unresponsive’ to treatment?
STUDY 2018 HTM file
Usage of low dead space syringes and association with hepatitis C prevalence amongst people who inject drugs in the UK
For people who share injecting equipment, ‘low dead space’ syringes may lead to a reduced risk of becoming infected with blood-borne viruses by limiting the volume of fluid that is drawn up but not injected. However, they may not (yet) be suitable for all types of injectors or injections.
STUDY 2020 HTM file
Comparative effectiveness of different treatment pathways for opioid use disorder
How do different pathways for the treatment of problem opioid use compare under real-world conditions? For US patients with health insurance, opioid substitution therapy was associated with the greatest risk reduction. However, its protective effect may not be fully realised while federal and insurance plan restrictions continue to limit access to this treatment option.
MATRIX CELL 2018 HTM file
Drug Treatment Matrix cell B3: Practitioners; Medical treatment
Seminal and key research and reviews on the influence of the practitioner in the medical treatment of drug dependence. Investigates the how clinician-patient relationships might be affected by enforcing clinic rules and the potential importance of doctors forming a “whole person’ relationship with patients.
MATRIX CELL 2018 HTM file
Drug Treatment Matrix cell C3: Management/supervision; Medical treatment
Seminal and key studies on the role of management and supervision in medical interventions and treatment in medical settings. Commentary considers how medication-based treatment can be (re)oriented to long-term recovery, the importance of the right dose, and whether we can we dispense with all but minimal counselling and therapy and supervised consumption of medications like methadone.
MATRIX CELL 2018 HTM file
Drug Treatment Matrix cell D3: Organisational functioning; Medical treatment
Seminal and key studies on how treatment organisations affect the implementation and effectiveness of medical interventions and treatment in medical settings. Focus is on UK and US understandings of what counts as a ‘recovery-oriented’ service and on US, Australian and Canadian studies which discovered and validated elements of these visions even before they were articulated.
MATRIX CELL 2020 HTM file
Alcohol Treatment Matrix cell C3: Management/supervision; Medical treatment
Seminal and key studies on the impact of management on medical interventions and treatment for problem drinking in medical settings. Asks how we can identify effective clinicians and effective medications, and highlights the remarkable transformation brought about in the 1950s at a US clinic which few referred patients attended and fewer still engaged with.
STUDY 2020 HTM file
Skin-cleaning among hospitalized people who inject drugs: a randomized controlled trial
Serious bacterial infections are among the most common medical complications in people who inject drugs. Study asks whether an intervention targeting hand washing, injection site skin cleaning, and needle cleaning could reduce the burden, using as its key measure the rate of visits to the emergency department.
MATRIX CELL 2018 HTM file
Drug Treatment Matrix cell A5: Interventions; Safeguarding the community
Seminal and key studies shedding light on treatment’s contribution to safeguarding the community and preventing crime. Commentary addresses two highly controversial issues, asking, “Can it ever be safe to leave children with seriously problematic drug users?”, and examining the ethical considerations and evidence on pressuring opioid-dependent offenders to take the opiate-blocker naltrexone.
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