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REVIEW 2004 PDF file 967Kb
Take the network into treatment
Distinguished US authors summarise the evidence for a new direction in the treatment of substance abuse problems - harnessing friends, lovers, sons, daughters and workmates to reconstruct the incentives in a client's life.
STUDY 2004 PDF file 159Kb
Retention is not just about motivation
Being motivated enough to cut drug use before treatment entry leads to better outcomes, but even after taking this in to account, this huge US study found outcomes improved the longer patients stayed in residential or non-residential programmes.
STUDY 2004 PDF file 109Kb
Rapid detoxification facilitates transfer to naltrexone but gains fade
Relative to usual procedures, in the Netherlands, Australia and the USA, rapid withdrawal under anaesthesia enabled more opiate dependent patients to transfer to naltrexone and remain opiate free in the short-term, but within a year gains had diminished.
STUDY 2008 HTM file
High risk of overdose death for opiate detoxification completers
Findings from Italy and Australia warn that detoxification without throughgoing stabilisation, preparation and aftercare is too often a band-aid measure which risks more harm then good.
REVIEW 2009 HTM file
Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence
A surprisingly small basket of randomised controlled trials (but one confirmed by other studies) supports the superiority of methadone maintenance over detoxification for patients prepared to be allocated to either option.
STUDY 2006 PDF file 152Kb
Naltrexone implants prevent opiate overdose
Short-acting opiate blockers are associated with high overdose rates when heroin-dependent patients stop taking them. This Australian study suggests that a product intended to block opiates for six months can overcome that problem, though patients may resort to sedatives instead.
STUDY 2006 PDF file 279Kb
British study makes a case for buprenorphine as first line heroin detox option
Compared to a standard lofexidine regime, buprenorphine was preferred by opiate dependent patients and enabled more to complete outpatient detoxification.
STUDY 2004 PDF file 191Kb
Clinically relevant comparison supports buprenorphine as methadone alternative
A large scale Australian study which approximated recommended clinical procedures found buprenorphine roughly equivalent to methadone as a maintenance treatment for opiate dependence and also roughly as cost-effective.
STUDY 2006 PDF file 162Kb
Long-acting depot naltrexone extends opiate abstinence
A long-acting version of the opiate blocking drug naltrexone nearly doubled the time heroin dependent patients were retained in abstinence-based treatment, creating an opiate-free space during which to begin the construction of non-addicted lifestyles.
NOTES 2010 PDF file 239Kb
Preventing unauthorised use of medications prescribed for the treatment of opiate addiction
Detailed and fully referenced notes on preventing the diversion of maintenance medications like methadone on to the illicit market, with an emphasis on the pros and cons of supervised consumption.
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