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You have found 219 entries after clicking on a search link (usually the MORE information link) in a matrix cell. Sorted by the main topic addressed, the list shows in orange the type of entry, year the original document was published (or if one of our own documents, the year last updated), and the type of file you will download when you click on the title. In blue is the document’s title followed by a brief description.

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STUDY 2004 PDF file 607Kb
Opiate antagonist treatment risks overdose

The most comprehensive recent study of serious medical incidents during and after treatment for opioid dependence highlighted the risk of overdose death when patients stop taking opiate-blocking drugs. In comparison, substitute prescribing was safer even after the patient had left treatment.

STUDY 2006 PDF file 152Kb
Naltrexone implants prevent opiate overdose

Short-acting opiate blockers are associated with high overdose rates when heroin-dependent patients stop taking them. This Australian study suggests that a product intended to block opiates for six months can overcome that problem, though patients may resort to sedatives instead.

STUDY 2006 PDF file 108Kb
1 in a 100 chance of dying after treatment with heroin-blocking drug

In Australia heroin-addicted patients trying to avoid relapse by taking the opiate-blocking drug naltrexone had at least a 1 in a 100 chance of dying within three months, usually from overdose in the weeks after treatment ended; the true figure may have been as high as 8 in a 100.

STUDY 2010 HTM file
Naltrexone implants compared to methadone: outcomes six months after prison release

In the first study of its kind opiate-dependent prisoners in Norway were randomly allocated to a six-month implant which blocks the effects of heroin or to methadone which substitutes for heroin as a way of bridging the period after release. Among the few interested in either option, they led to equivalent reductions in opiate use and crime.

STUDY 2010 HTM file
Favorable mortality profile of naltrexone implants for opiate addiction

Few treatments for opiate addiction arouse as much controversy as naltrexone implants. Inserted under the skin, these block the effects of heroin for up to several months - for some, a magic bullet, for others, an unsafe and ethically dubious experiment. More evidence from Australia that the overdose death risk is less than with oral forms of the drug.

DOCUMENT 2015 HTM file
American Society of Addiction Medicine (ASAM) national practice guideline for the use of medications in the treatment of addiction involving opioid use

From the USA’s professional society for clinicians and allied professionals in the field of addiction medicine, comprehensive recommendations on how doctors can use medications to treat addiction to heroin and other opioids.

STUDY 2009 HTM file
Naltrexone implants after in-patient treatment for opioid dependence: randomised controlled trial

In the first randomised trial, implants which block opiate-type drugs for months helped heroin addicts in Norway avoid relapse after detoxification. If these or allied products gain a UK licence, they could help pave the way to abstinence for the minority of suitable addicts.

DOCUMENT 2017 HTM file
Drug misuse and dependence: UK guidelines on clinical management

Last published in 2007, there is no more important document for UK clinicians involved in treating problem drug use than the so-called ‘Orange guidelines’. This major update offers detailed guidance on the range of problems, settings and patients clinicians encounter, substantially informing judgements of what constitutes good medical practice.

STUDY 2002 PDF file 155Kb
Drug users who continue to inject still respond well to hepatitis C treatment

UK guidance from NICE and the Department of Health on the treatment of hepatitis C infection may need to be revised in the light of studies showing that drug users who continue to inject can nevertheless respond well to the treatment.

REVIEW 2008 HTM file
Critical issues in the treatment of hepatitis C virus infection in methadone maintenance patients

European and US studies show that methadone patients stick with therapy for hepatitis C disease and do as well as other patients, bolstering the case for drug services to encourage clients to consider diagnostic testing and therapy.


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