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You have found 212 entries after clicking on a search link (usually the MORE information link) in a matrix cell. Starting with analyses of the most recently published documents, the list shows in orange the type of entry, year the original document was published (or if one of our own documents, the year last updated), and the type of file you will download when you click on the title. In blue is the document’s title followed by a brief description.

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REVIEW 2016 HTM file
Are take-home naloxone programmes effective? Systematic review utilizing application of the Bradford Hill criteria

How confident can we be that take-home naloxone programmes are effective without the ‘gold standard’ randomised trial? Judged against nine criteria for establishing the presumption of causality, evidence that the provision of naloxone reduces overdose-related deaths among opioid users.

HOT TOPIC 2016 HTM file
Harm reduction: what’s it for?

‘Hot topics’ offer background and analysis on important issues which sometimes generate heated debate. Opposing agendas have led to a shifting balance between seeing harm-reduction as acceptable only in the service of the greater good of reducing or eliminating drug use, versus seeing it as the overriding objective, one which should never be sacrificed to an anti-drugs agenda.

STUDY 2015 HTM file
Estimation of life expectancy and the expected years of life lost among heroin users in the era of opioid substitution treatment (OST) in Taiwan

After adjusting for other influences, heroin users diagnosed as dependent at a psychiatric centre in Taiwan who started opioid substitution treatment lived nearly eight years longer than those who did not enter treatment. However, the treated group were more likely to commit suicide, usually associated with a history of depression.

DOCUMENT 2015 HTM file
American Society of Addiction Medicine (ASAM) national practice guideline for the use of medications in the treatment of addiction involving opioid use

From the USA’s professional society for clinicians and allied professionals in the field of addiction medicine, comprehensive recommendations on how doctors can use medications to treat addiction to heroin and other opioids.

STUDY 2015 HTM file
A longitudinal study of hepatitis C virus testing and infection status notification on behaviour change in people who inject drugs

Using data pooled from studies in three countries, researchers examined the impact of hepatitis C testing and counselling – and of testing positive versus negative – on whether people who inject drugs become more or less likely to risk infection.

STUDY 2015 HTM file
Risk of mortality on and off methadone substitution treatment in primary care: a national cohort study

Primary care methadone patients in Ireland were nearly four times more likely to die during periods out of treatment; the first few weeks after leaving were the peak risk period. The study’s support for unbroken, long-term treatment runs counter to recent UK government policy.

STUDY 2015 HTM file
Impact of opioid substitution therapy for Scotland’s prisoners on drug-related deaths soon after prisoner release

Failure to find effects concentrated in the first two weeks after release persuaded analysts that widespread methadone prescribing in Scottish prisons from 2002 did not reduce the rate of drug-related deaths after release. But over 12 weeks the rate did fall substantially, and methadone treatment may have helped.

STUDY 2015 HTM file
Hepatitis C virus treatment as prevention among injecting drug users: who should we cure first?

In the UK context, this study’s findings imply that to prevent new cases it is best to focus expensive new treatments for hepatitis C infection on injectors who infrequently share their injecting equipment – patients most likely to be found and recruited via needle exchanges and addiction treatment services.

STUDY 2015 HTM file
The impact of a Housing First randomized controlled trial on substance use problems among homeless individuals with mental illness

This intervention based on housing first led to significantly greater reductions in drinking problems after 14 months, but not in problems with other substances.

STUDY 2015 HTM file
Randomized controlled trial of motivational interviewing for reducing injection risk behaviours among people who inject drugs

Injectors at risk of infection due to sharing equipment responded best to brief risk-reduction counselling based on motivational rather than educational principles, offering a way to augment the benefits of harm reduction services.


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