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From Germany the first trial to rigorously test high doses of the muscle-relaxant baclofen for the treatment of dependent drinking found post-detoxification drinking reductions of a magnitude rarely seen. Other trials have been less positive, and serious safety concerns may limit the drug’s use.
From France the first study to randomly allocate patients to start methadone maintenance either in primary care or at a specialist centre found primary care more attractive to patients, and no less effective at reducing street-opioid use and promoting engagement and retention.
Can monthly injections of extended-release naltrexone be considered on a par with the standard daily opioid substitute in Norway for people wanting to maintain abstinence from heroin?
MATRIX CELL 2017 HTM file
Alcohol Treatment Matrix cell E3: Treatment systems; Medical treatment
Seminal and key studies on local, regional and national systems for effectively and cost-effectively providing medical interventions and treatment in medical settings.
MATRIX CELL 2016 HTM file
Alcohol Matrix cell E2: Treatment systems; Generic and cross-cutting issues
The most important studies on local, regional and national systems for effectively and cost-effectively providing treatment. One of 25 cells in the alcohol matrix. Also highlights the most useful reviews and practice guidelines and offers a customised one-click search for more on the Effectiveness Bank database.
This German study shows that heroin maintenance treatment can contribute to greater reductions in drug and property offences than methadone maintenance.
REVIEW 2010 HTM file
Gender issues in the pharmacotherapy of opioid-addicted women: Buprenorphine
This paper reviews the treatment options for women dependent on opiate-type drugs, focussing on buprenorphine, including its safety for the treatment of pregnant and breastfeeding women.
Unless there is a compelling medical or social contraindication, results of extended treatment in the Dutch heroin prescribing trials suggest treatment should be continued as long as possible for heroin-addicted patients who have been failed by methadone but benefit from being prescribed heroin.
Ironically, the fact that opiate substitute prescribing has been opposed and limited in Sweden has meant that country has been able provide solid evidence of its lifesaving potential. This study concluded that easing the restrictions was associated with and may have led to fewer opiate-related deaths.
STUDY 2014 HTM file
Drugs: international comparators
After seeing how drug policy worked overseas, UK government ministers and officials returned saying, “there is no apparent correlation between the ‘toughness’ of a country’s approach and the prevalence of adult drug use”, and that “better health outcomes for drug users cannot be shown to be a direct result of the enforcement approach”.
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