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You have found 29 entries after clicking the GO button or a search link in a hot topic. Sorted by the main topic addressed, the list shows in orange the type of entry, year the original document was published (or if one of our own documents, the year last updated), and the type of file you will download when you click on the title. In blue is the document’s title followed by a brief description.

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MATRIX CELL 2018 HTM file
Drug Treatment Matrix cell D3: Organisational functioning; Medical treatment

Seminal and key studies on how treatment organisations affect the implementation and effectiveness of medical interventions and treatment in medical settings. Focus is on UK and US understandings of what counts as a ‘recovery-oriented’ service and on US, Australian and Canadian studies which discovered and validated elements of these visions even before they were articulated.

STUDY 2015 HTM file
Impact of treatment for opioid dependence on fatal drug-related poisoning: a national cohort study in England

Implication of this English study is that to save the lives of people dependent on heroin or similar drugs, they should be engaged and retained in substitute prescribing programmes like methadone maintenance until there is little risk of their relapsing after leaving. Shortly after leaving residential/inpatient settings was the highest risk period.

REVIEW 2017 HTM file
Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies

Opioid substitution therapy is a safe and effective approach for suppressing illicit opioid use. Helping to guide optimal provision, this review investigates the relative effects of methadone and buprenorphine on the rate of mortality over time.

STUDY 2011 HTM file
Outpatient versus inpatient opioid detoxification: a randomized controlled trial

Methadone maintained heroin-dependent patients in Birmingham (UK) randomised to inpatient v. outpatient lofexidine-based detoxification rarely sustained long-term opioid abstinence; return to maintenance was the typical outcome.

STUDY 1999 PDF file 255Kb
Methadone treatment cost-effective life saver

Three studies which show that getting in to and staying in methadone treatment cost-effectively saves the lives of heroin addicts. Conversely, being denied treatment or discharged for rule-breaking costs lives.

STUDY 2004 PDF file 159Kb
Methadone maintenance as low-cost lifesaver

US studies find that even when slow methadone detoxification is bolstered by psychosocial therapy and aftercare, methadone maintenance does better at prolonging the lives of opiate-dependent patients at relatively little extra cost.

STUDY 2008 HTM file
Mortality prior to, during, and after opioid maintenance treatment (OMT): a national prospective cross-registry study

Limited access to opiate substitute prescribing in Norway opened a window on its powerful lifesaving potential, a view obscured in countries where barriers create a confounding selection effect or where everyone who needs and wants this treatment can quickly get it.

STUDY 2010 HTM file
Risk of death during and after opiate substitution treatment in primary care: prospective observational study in UK

This British study concluded that it takes extended opiate substitute prescribing to realise the treatment's life-saving potential. The implication is that the current push to get people off methadone sooner could cost lives.

STUDY 2011 HTM file
A good quality of life under the influence of methadone: a qualitative study among opiate-dependent individuals

Opiate dependent methadone patients in Belgium give their own accounts of what for them constitutes a good quality of life. Generally they want what other people want: a meaningful, independent life and supportive relationships. Methadone creates the preconditions for such a life at the same time as it limits its achievement.

DOCUMENT 2012 HTM file
Medications in recovery: re-orientating drug dependence treatment

On behalf of the UK government an expert group has developed and documented a clinical consensus on how prescribing-based treatment for heroin addiction can be made more recovery-oriented in line with national strategy. Their report will be the main reference point in tussles over what recovery means for methadone services and patients.


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