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STUDY 2011 HTM file
What is the role of harm reduction when drug users say they want abstinence?
A team including one of the researchers responsible for the original finding have queried the interpretation of the highly influential report from a national Scottish study that most drug users starting treatment wanted to become abstinent. On the basis of in-depth interviews, they caution that it is just not that simple.
REVIEW 2010 HTM file
Quality of life among opiate-dependent individuals: a review of the literature
The first systematic review of research on the quality of life of opiate users finds this generally improves once they enter substitute prescribing treatments, but that few studies have assessed what counts as a good life from the point of view of the patient.
ABSTRACT 2011 HTM file
Guidance for the use of substitute prescribing in the treatment of opioid dependence in primary care
Evidence-based guidance for British GPs on how to withdraw heroin and other opioid addicts from opiate-type drugs or to maintain them by long-term prescribing of legal substitutes, with a focus on the use methadone and buprenorphine, the main medications used for these purposes in the UK.
STUDY 2010 HTM file
The SUMMIT Trial: a field comparison of buprenorphine versus methadone maintenance treatment
Compared to methadone, buprenorphine is more often chosen in a make-or-break attempt to divorce oneself from illicit opiates found the first large-scale study to compare the drugs in real-life conditions at a British opiate addiction maintenance treatment programme.
REVIEW 2010 HTM file
Heroin anticraving medications: a systematic review
The observation that craving can precipitate relapse to heroin use or drop-out even among methadone-maintained patients led to this search for evidence that other medications can help suppress the urge to use; buprenorphine had the most extensive positive research record to date.
NOTES 2010 PDF file 239Kb
Preventing unauthorised use of medications prescribed for the treatment of opiate addiction
Detailed and fully referenced notes on preventing the diversion of maintenance medications like methadone on to the illicit market, with an emphasis on the pros and cons of supervised consumption.
STUDY 2006 PDF file 108Kb
1 in a 100 chance of dying after treatment with heroin-blocking drug
In Australia heroin-addicted patients trying to avoid relapse by taking the opiate-blocking drug naltrexone had at least a 1 in a 100 chance of dying within three months, usually from overdose in the weeks after treatment ended; the true figure may have been as high as 8 in a 100.
REVIEW 2009 HTM file
Pharmacotherapies for the treatment of opioid dependence: efficacy, cost-effectiveness and implementation guidelines
From some of the same Australian authors who produced classic texts on maintenance prescribing for heroin addiction, a major new text analysing research on all types of drug-based interventions including maintenance, opiate-blocking drugs, and managing withdrawal.
About a third of Britain's heroin dependent patients also have problems with crack cocaine. Can opiate substitute prescribing help with both problems, and which special anti-cocaine therapies are worth adding on? This review trawled the international research for the answers.
REVIEW 2008 HTM file
Treating pregnant women dependent on opioids is not the same as treating pregnancy and opioid dependence: a knowledge synthesis for better treatment for women and neonates
New guidance on managing pregnant women dependent on heroin and allied drugs emphasises that maintenance prescribing is the core treatment but holistic, individualised care is essential; its warnings about the dangers of detoxification are not universally accepted.
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