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You have found 57 entries. Starting with analyses of the most recently published documents, the list shows in orange the type of entry, year the original document was published (or if one of our own documents, the year last updated), and the type of file you will download when you click on the title. In blue is the document’s title followed by a brief description.

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REVIEW 2010 HTM file
Long-acting depot formulations of naltrexone for heroin dependence: a review

Researcher responsible for a major Russian trial of long-acting naltrexone for the treatment of heroin dependence reviews the effectiveness and safety of this form of the drug and of another long-acting form implanted under the skin.

STUDY 2009 HTM file
Improving clinical outcomes in treating heroin dependence: randomized, controlled trial of oral or implant naltrexone

The first trial of implanted versus oral naltrexone found that the implants' extended opiate-blocking action helps avoid relapse to regular opiate use – but the action was not as extended as hoped, non-opiate use was greater, and there were more unpleasant side-effects.

REVIEW 2009 HTM file
Pharmacotherapies for the treatment of opioid dependence: efficacy, cost-effectiveness and implementation guidelines

From some of the same Australian authors who produced classic texts on maintenance prescribing for heroin addiction, a major new text analysing research on all types of drug-based interventions including maintenance, opiate-blocking drugs, and managing withdrawal.

DOCUMENT 2009 HTM file
Guidelines for the psychosocially assisted pharmacological treatment of opioid dependence

Unequivocal backing from UN agencies for methadone and other forms of long term maintenance treatments as the prime modality for the treatment of dependence on heroin and allied drugs. In contrast say the experts, detoxification results in poor long term outcomes.

STUDY 2008 HTM file
High risk of overdose death for opiate detoxification completers

Findings from Italy and Australia warn that detoxification without throughgoing stabilisation, preparation and aftercare is too often a band-aid measure which risks more harm then good.

REVIEW 2008 HTM file
The search for medications to treat stimulant dependence

Expert and accessible review of the state of play in finding effective and (to the patients) acceptable medications to initiate or sustain abstinence from cocaine or methamphetamine. Though extensive, the results of this US-led search have so far been disappointing.

STUDY 2008 HTM file
Maintenance treatment with buprenorphine and naltrexone for heroin dependence in Malaysia: a randomised, double-blind, placebo-controlled trial

This unique randomised trial tested what would happen if detoxified opiate addicts were then maintained on a substitute drug, on an opiate-blocking medication, or simply counselled. The results led to the introduction of methadone prescribing programmes in Malaysia.

STUDY 2006 PDF file 152Kb
Naltrexone implants prevent opiate overdose

Short-acting opiate blockers are associated with high overdose rates when heroin-dependent patients stop taking them. This Australian study suggests that a product intended to block opiates for six months can overcome that problem, though patients may resort to sedatives instead.

STUDY 2006 PDF file 162Kb
Long-acting depot naltrexone extends opiate abstinence

A long-acting version of the opiate blocking drug naltrexone nearly doubled the time heroin dependent patients were retained in abstinence-based treatment, creating an opiate-free space during which to begin the construction of non-addicted lifestyles.

STUDY 2006 PDF file 108Kb
1 in a 100 chance of dying after treatment with heroin-blocking drug

In Australia heroin-addicted patients trying to avoid relapse by taking the opiate-blocking drug naltrexone had at least a 1 in a 100 chance of dying within three months, usually from overdose in the weeks after treatment ended; the true figure may have been as high as 8 in a 100.

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