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REVIEW 2009 HTM file
Pharmacotherapies for the treatment of opioid dependence: efficacy, cost-effectiveness and implementation guidelines
From some of the same Australian authors who produced classic texts on maintenance prescribing for heroin addiction, a major new text analysing research on all types of drug-based interventions including maintenance, opiate-blocking drugs, and managing withdrawal.
STUDY 2006 PDF file 152Kb
Naltrexone implants prevent opiate overdose
Short-acting opiate blockers are associated with high overdose rates when heroin-dependent patients stop taking them. This Australian study suggests that a product intended to block opiates for six months can overcome that problem, though patients may resort to sedatives instead.
STUDY 2009 HTM file
Improving clinical outcomes in treating heroin dependence: randomized, controlled trial of oral or implant naltrexone
The first trial of implanted versus oral naltrexone found that the implants' extended opiate-blocking action helps avoid relapse to regular opiate use – but the action was not as extended as hoped, non-opiate use was greater, and there were more unpleasant side-effects.
STUDY 2003 PDF file 164Kb
Naltrexone implants could reduce the early relapse rate after detoxification
Studies from the UK and Germany suggest that subcutaneous implants of naltrexone which block the effects of heroin for up to seven weeks could help reduce the early relapse rate after detoxification more effectively than the oral form of the medication.
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