Hot topic search results

You have found 95 entries after clicking the GO button or a search link in a hot topic. Starting with analyses of the most recently published documents, the list shows in orange the type of entry, year the original document was published (or if one of our own documents, the year last updated), and the type of file you will download when you click on the title. In blue is the document’s title followed by a brief description.

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STUDY 2020 HTM file
Comparative effectiveness of different treatment pathways for opioid use disorder

How do different pathways for the treatment of problem opioid use compare under real-world conditions? For US patients with health insurance, opioid substitution therapy was associated with the greatest risk reduction. However, its protective effect may not be fully realised while federal and insurance plan restrictions continue to limit access to this treatment option.

STUDY 2019 HTM file
Drug safety testing, disposals and dealing in an English field: Exploring the operational and behavioural outcomes of the UK’s first onsite ‘drug checking’ service

In a year when drug-related deaths in the UK had peaked, a pioneering study of drug safety testing was conducted on festival grounds. Its impact on drug-related harm was measured at various levels, including drug-related hospital admissions, behaviours of 230 people who received harm reduction advice, and actions that stakeholders took after receiving information about drugs being mis-sold or contaminated.

STUDY 2019 HTM file
ACT pill testing trial 2019: program evaluation

Independent evaluation suggests reasons to have confidence in the harm reduction benefits of ‘pill testing’. However, the narrow scope of the drug testing service adopted at this Australian festival may not have been adequately understood by stakeholders.

STUDY 2019 HTM file
Modelling the combined impact of interventions in averting deaths during a synthetic-opioid overdose epidemic

In the Canadian province of British Columbia there was a rapid rise in overdose deaths from 2015, leading to the declaration of a public health emergency in 2016. The response rested on three key interventions: take-home naloxone, opioid substitution therapy, and drug consumption rooms. The province’s highly detailed surveillance data offered an opportunity to estimate their collective and individual impacts on opioid overdose deaths.

REVIEW 2019 HTM file
Supervised consumption sites: a nuanced assessment of the causal evidence

How high should the evidence bar be set when deciding whether to endorse drug consumption rooms?

STUDY 2019 HTM file
One opioid user saving another: the first study of an opioid overdose-reversal and naloxone distribution program addressing hard-to-reach drug scenes in Denmark

A Danish programme targeted potential bystanders of opioid overdoses, providing training and supplies of the ‘overdose antidote’ naloxone. People who use opioids were the most likely to intervene in an overdose situation, highlighting their positive role as “public health collaborators”.

STUDY 2019 HTM file
Do electronic health record prompts increase take-home naloxone administration for emergency department patients after an opioid overdose?

Emergency department physicians regularly treat people who have had an opioid overdose, but they may not be making the most of the opportunity to provide take-home naloxone. Can a prompt in the patients’ electronic health records boost prescribing of this lifesaving ‘overdose antidote’?

STUDY 2018 HTM file
A randomized, open label trial of methadone continuation versus forced withdrawal in a combined US prison and jail: findings at 12 months post-release

From the USA, a rare randomised trial found in favour of continuing methadone maintenance when patients entered prison rather than compulsory withdrawal. The potential benefits were most apparent in the near-100% continuation of protective treatment during the highly overdose-prone weeks after leaving prison.

STUDY 2018 HTM file
The impact of buprenorphine and methadone on mortality: a primary care cohort study in the United Kingdom

Buprenorphine may be associated with a lower risk of mortality than methadone among people engaged in opioid substitution treatment – but is the pattern of short treatment duration in the UK preventing maximal impact at a population level?

HOT TOPIC 2018 HTM file
Ethics and evidence on naltrexone treatment of offenders

‘Hot topics’ offer background and analysis on important issues which sometimes generate heated debate. Opinion is sharply divided on the ethics and effectiveness of pressuring opioid-dependent offenders to take the opiate-blocker naltrexone. Especially sharp is the controversy over long-acting products not approved for medical practice in the UK. Do they constitute an unacceptable infringement of autonomy, or is forcing them on some offenders as caring as holding back someone about to (by choice or not) walk off a cliff?

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