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You have found 95 entries after clicking the GO button or a search link in a hot topic. Starting with the most recently added or updated entries, the list shows in orange the type of entry, year the original document was published (or if one of our own documents, the year last updated), and the type of file you will download when you click on the title. In blue is the document’s title followed by a brief description.

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STUDY 2019 HTM file
Do electronic health record prompts increase take-home naloxone administration for emergency department patients after an opioid overdose?

[Consultation draft subject to amendment and correction.] Emergency department physicians regularly treat people who have had an opioid overdose, but may not be making the most of the opportunity to provide take-home naloxone. Study tests the effectiveness of a prompt in the patients’ electronic health records for boosting physician prescribing of this ‘overdose antidote’.

STUDY 2020 HTM file
Comparative effectiveness of different treatment pathways for opioid use disorder

How do different pathways for the treatment of problem opioid use compare under real-world conditions? For US patients with health insurance, opioid substitution therapy was associated with the greatest risk reduction. However, its protective effect may not be fully realised while federal and insurance plan restrictions continue to limit access to this treatment option.

STUDY 2019 HTM file
Modelling the combined impact of interventions in averting deaths during a synthetic-opioid overdose epidemic

In the Canadian province of British Columbia there was a rapid rise in overdose deaths from 2015, leading to the declaration of a public health emergency in 2016. The response rested on three key interventions: take-home naloxone, opioid substitution therapy, and drug consumption rooms. The province’s highly detailed surveillance data offered an opportunity to estimate their collective and individual impacts on opioid overdose deaths.

STUDY 2019 HTM file
One opioid user saving another: the first study of an opioid overdose-reversal and naloxone distribution program addressing hard-to-reach drug scenes in Denmark

A Danish programme targeted potential bystanders of opioid overdoses, providing training and supplies of the ‘overdose antidote’ naloxone. People who use opioids were the most likely to intervene in an overdose situation, highlighting their positive role as “public health collaborators”.

STUDY 2019 HTM file
ACT pill testing trial 2019: program evaluation

[Consultation draft subject to amendment and correction.] Assessing the implementation and outcomes of drug safety testing at an Australian festival, this independent evaluation found reasons to have confidence in, and in the future extend, the harm reduction benefits.

REVIEW 2019 HTM file
Supervised consumption sites: a nuanced assessment of the causal evidence

How high should the evidence bar be set when deciding whether to endorse drug consumption rooms?

STUDY 2019 HTM file
Drug safety testing, disposals and dealing in an English field: Exploring the operational and behavioural outcomes of the UK’s first onsite ‘drug checking’ service

In a year when drug-related deaths in the UK had peaked, a pioneering study of drug safety testing was conducted on festival grounds. Its impact on drug-related harm was measured at various levels, including drug-related hospital admissions, behaviours of 230 people who received harm reduction advice, and actions that stakeholders took after receiving information about drugs being mis-sold or contaminated.

REVIEW 2017 HTM file
Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies

Opioid substitution therapy is a safe and effective approach for suppressing illicit opioid use. Helping to guide optimal provision, this review investigates the relative effects of methadone and buprenorphine on the rate of mortality over time.

STUDY 2018 HTM file
Effect of initiating drug treatment on the risk of drug-related poisoning death and acquisitive crime among offending heroin users

At issue was whether by successfully referring heroin users to treatment, probation services in England would protect them from fatal overdose and prevent drug-related crime. Yes to one, but not the other, were the answers; in fact, crime went up.

REVIEW 2016 HTM file
Are take-home naloxone programmes effective? Systematic review utilizing application of the Bradford Hill criteria

How confident can we be that take-home naloxone programmes are effective without the ‘gold standard’ randomised trial? Judged against nine criteria for establishing the presumption of causality, evidence that the provision of naloxone reduces overdose-related deaths among opioid users.


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