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You have found 124 entries after clicking on a search link (usually the MORE information link) in a matrix cell. Sorted by the main topic addressed, the list shows in orange the type of entry, year the original document was published (or if one of our own documents, the year last updated), and the type of file you will download when you click on the title. In blue is the document’s title followed by a brief description.

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STUDY 2018 HTM file
Impact of current and scaled-up levels of hepatitis C prevention and treatment interventions for people who inject drugs in three UK settings – what is required to achieve the WHO’s HCV elimination targets?

What would it take for the UK to meet the World Health Organization’s target of a 90% reduction in hepatitis C by 2030? According to projections in three diverse areas, current levels of harm reduction services are averting a great deal of transmission, and adding only moderate rates of treatment for hepatitis C would put Britain on course to achieve the elimination target.

STUDY 2019 HTM file
Evaluating the cost-effectiveness of existing needle and syringe programmes in preventing hepatitis C transmission in people who inject drugs

What would happen to rates of infection with hepatitis C if we closed down all the needle exchanges? In three UK municipalities, the answers were predicted to be more infections, lost low-cost opportunities to improve and save lives, and in two of the areas, greater health-related costs overall. Conclusion was that these services are among the best investments UK health services can make. town

DOCUMENT 2014 HTM file
Community management of opioid overdose

Experts convened by the World Health Organization judged the risk-benefit profile to be strongly in favour of naloxone distribution to prevent opiate overdose deaths, but also cautioned that this “does not address the underlying causes of opioid overdose”.

STUDY 2015 HTM file
Impact of treatment for opioid dependence on fatal drug-related poisoning: a national cohort study in England

Implication of this English study is that to save the lives of people dependent on heroin or similar drugs, they should be engaged and retained in substitute prescribing programmes like methadone maintenance until there is little risk of their relapsing after leaving. Shortly after leaving residential/inpatient settings was the highest risk period.

STUDY 2013 HTM file
Cost-effectiveness of distributing naloxone to heroin users for lay overdose reversal

The first simulation of the cost-effectiveness of supplying naloxone kits to heroin users to enable them to prevent overdose deaths estimates that in the US context these programmes would be well within the range considered a cost-effective health intervention. Findings are likely to broadly apply to the UK, one weak link being whether drug users given the kits actually carry them around.

DOCUMENT 2016 HTM file
Harm reduction database Wales: take home naloxone 2015–16

Report charting the roll-out of ‘take-home naloxone’ in Wales up to 2016, a harm-reduction measure implemented to prevent deaths involving opiate-type drugs.

STUDY 2016 HTM file
Reducing opioid-related deaths in the UK

The UK’s official drug policy advisers conclude that the ageing profile of heroin users with increasingly complex health needs has contributed to recent increases in drug-related deaths, and that to hold down the increases government must maintain investment in substitute prescribing programmes like methadone maintenance.

HOT TOPIC 2017 HTM file
Overdose deaths in the UK: crisis and response

One of our selection of hot topics – important issues which sometimes generate heated debate. Why did the fall in UK drug overdose deaths in 2009 to 2012 so decisively reverse in the following years? A life-threatening turn away from harm reduction, or simply an ageing population of heroin users?

STUDY 2016 HTM file
Effectiveness of Scotland’s National Naloxone Programme for reducing opioid-related deaths: a before (2006–10) versus after (2011–13) comparison

In 2011 Scotland became the first country to fund a national policy of distributing the opiate-blocker naloxone to prevent deaths involving opiate-type drugs. According to this evaluation it did prevent deaths where the effect was most likely to be seen – in the weeks after release from prison.

HOT TOPIC 2017 HTM file
Overdose antidote naloxone takes harm-reduction centre stage

‘Hot topics’ offer background and analysis on important issues which sometimes generate heated debate. National programmes distributing the opiate overdose antidote naloxone have become the great hope for curbing the rise in overdose deaths, but England is lagging behind the rest of the UK – and planning for the likelihood not of recovery but relapse may for some services and patients be hard to accept.


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