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You have found 124 entries after clicking on a search link (usually the MORE information link) in a matrix cell. Sorted by the main topic addressed, the list shows in orange the type of entry, year the original document was published (or if one of our own documents, the year last updated), and the type of file you will download when you click on the title. In blue is the document’s title followed by a brief description.

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DOCUMENT 2014 HTM file
Time limiting opioid substitution therapy

Rather than being ‘parked’ on methadone, generally Britain’s heroin-addicted patients leave too soon to fully benefit, argue official government advisers on drug policy. Their report unambiguously countered concerns within the current UK government over methadone maintenance.

STUDY 2010 HTM file
Were the changes to Sweden’s maintenance treatment policy 2000–06 related to changes in opiate-related mortality and morbidity?

Ironically, the fact that opiate substitute prescribing has been opposed and limited in Sweden has meant that country has been able provide solid evidence of its lifesaving potential. This study concluded that easing the restrictions was associated with and may have led to fewer opiate-related deaths.

STUDY 2018 HTM file
The impact of buprenorphine and methadone on mortality: a primary care cohort study in the United Kingdom

Buprenorphine may be associated with a lower risk of mortality than methadone among people engaged in opioid substitution treatment – but is the pattern of short treatment duration in the UK preventing maximal impact at a population level?

REVIEW 2008 HTM file
International review and UK guidance weigh merits of buprenorphine versus methadone maintenance

Analysis which informed new UK guidelines on the maintenance treatment of opiate dependence concludes that buprenorphine has slightly less 'holding power' than methadone but equivalent suppression of opiate use.

STUDY 2004 PDF file 191Kb
Clinically relevant comparison supports buprenorphine as methadone alternative

A large scale Australian study which approximated recommended clinical procedures found buprenorphine roughly equivalent to methadone as a maintenance treatment for opiate dependence and also roughly as cost-effective.

STUDY 2000 PDF file 144Kb
Methadone's failures respond to heroin

A large-scale trial in Switzerland suggests that despite failures with other treatments, many long-term heroin addicts respond well to a treatment based on injectable heroin.

STUDY 2001 PDF file 107Kb
Injectable methadone maintenance suitable for more severely affected heroin addicts

Conducted in London, the first study to randomise opiate dependent patients to injectable versus oral methadone maintenance suggested that the injectable option is preferable for addicts with relatively severe health and psychological problems.

REVIEW 2003 PDF file 925Kb
Role Reversal

Controversial, expensive, yet promising so much, interest is increasing in prescribing heroin to heroin addicts. Just five studies hold what answers there are to whether this can work, including a probably unrepeatable early British study.

DOCUMENT 2006 PDF file 1326Kb
The Rolleston legacy

In British drug policy no document has more claim to the term 'classic' than the 1926 Rolleston report, which enshrined doctors' freedom to prescribe opiates to opiate addicts.

REVIEW 2012 HTM file
New heroin-assisted treatment: Recent evidence and current practices of supervised injectable heroin treatment in Europe and beyond

Prescribing oral methadone to heroin addicts divides opinions, but prescribing injectable heroin elevates the controversy to another level. Fortunately we now have six randomised clinical trials involving over 1500 patients to ground us in the evidence – and this European Union review to pull it all together.


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