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You have found 239 entries after clicking on a search link (usually the MORE information link) in a matrix cell. Starting with the most recently added or updated entries, the list shows in orange the type of entry, year the original document was published (or if one of our own documents, the year last updated), and the type of file you will download when you click on the title. In blue is the document’s title followed by a brief description.

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REVIEW 2018 HTM file
Interventions to reduce the negative effects of alcohol consumption in older adults: a systematic review

The first review to focus on alcohol interventions for older people found some evidence that psychosocial interventions such as counselling and brief advice were effective, but the studies lacked sufficient detail to determine which elements of the interventions might be having an effect.

STUDY 2012 HTM file
Does active referral by a doctor or 12-step peer improve 12-step meeting attendance? Results from a pilot randomised control trial

In the context of current UK policy, this is a key study, testing the ambition to extend recovery beyond formal treatment by systematically linking patients to mutual aid groups, the main way it is being suggested commissioners can square the circle of doing more (recovery is seen as a whole-life transformation) with less.

STUDY 2017 HTM file
Preventing alcohol and tobacco exposed pregnancies: CHOICES Plus in primary care

Compared to brief advice, the CHOICES Plus intervention significantly lowered the risk of alcohol- and tobacco-exposed pregnancies among women in a low-income primary care population. This US-based trial illustrates the efficacy of a bundle of ‘pre-conception’ services for risky drinking, smoking, and ineffective contraception.

STUDY 2015 HTM file
High-dose baclofen for the treatment of alcohol dependence (BACLAD study): A randomized, placebo-controlled trial

From Germany the first trial to rigorously test high doses of the muscle-relaxant baclofen for the treatment of dependent drinking found post-detoxification drinking reductions of a magnitude rarely seen. Other trials have been less positive, and serious safety concerns may limit the drug’s use.

STUDY 2017 HTM file
Effectiveness of injectable extended-release naltrexone vs daily buprenorphine–naloxone for opioid dependence: A randomized clinical noninferiority trial

Can monthly injections of extended-release naltrexone be considered on a par with the standard daily opioid substitute in Norway for people wanting to maintain abstinence from heroin?

REVIEW 2017 HTM file
Pharmacologically controlled drinking in the treatment of alcohol dependence or alcohol use disorders: a systematic review with direct and network meta-analyses on nalmefene, naltrexone, acamprosate, baclofen and topiramate

In 2013 nalmefene was authorised for moderating drinking among patients not in need of detoxification, extending pharmacotherapy to less dependent drinkers. Though uniquely authorised for this purpose, this review found other (and probably cheaper) drugs have been just as or possibly more effective, but for none was there high quality evidence.

STUDY 2017 HTM file
Impact of financial incentives on alcohol consumption recording in primary health care among adults with schizophrenia and other psychoses: a cross-sectional and retrospective cohort study

UK study of how Quality and Outcomes Framework incentives for primary care boosted alcohol screening among patients with severe mental illness shows what could have happened had the incentives been extended across the entire primary care caseload.

HOT TOPIC 2017 HTM file
‘My GP says I drink too much’: screening and brief intervention

One of our hot topics – important issues which sometimes generate heated debate. In the absence of more or less inescapable impediments to heavy drinking like ramping up the price of cheap alcohol, widespread screening and brief advice have been the great hope for drink-related public health improvements. Patchy effectiveness and poor implementation have led that ambition to be questioned.

HOT TOPIC 2017 HTM file
Substance use treatment as part of a ‘wrap-around’ package of care

One of our hot topic essays on important issues which sometimes generate heated debate. Asks whether supplementing addiction treatment with ‘wrap-around’ services is a distraction, or part of the core business of sustainably overcoming addiction. What’s for sure is that mental health, social and material resources, and the wherewithal for social inclusion, are all often lacking in addiction treatment caseloads; but does addressing these promote recovery?

STUDY 2014 HTM file
A ‘symptom-triggered’ approach to alcohol withdrawal management

Providing medication in response to symptoms of alcohol withdrawal instead of routinely improved the outcomes of patients in acute hospital settings – reducing the duration of treatment and the amount of medication used.


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