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You have found 129 entries after clicking the GO button or a search link in a hot topic. Sorted by the main topic addressed, the list shows in orange the type of entry, year the original document was published (or if one of our own documents, the year last updated), and the type of file you will download when you click on the title. In blue is the document’s title followed by a brief description.

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REVIEW 2010 HTM file
A review of opioid dependence treatment: pharmacological and psychosocial interventions to treat opioid addiction

This wide-ranging review uniquely draws together findings from authoritative reviews of rigorous research conducted for the Cochrane collaboration and later studies concerned with the pharmacological and psychosocial treatment of dependence on opiate-type drugs like heroin, concluding that retention is the common key to success.

STUDY 2012 HTM file
A pilot randomised controlled trial of brief versus twice weekly versus standard supervised consumption in patients on opiate maintenance treatment

What happens when opiate-addicted patients are suddenly no longer required to take their methadone under supervision but can take it away from the pharmacy? In Scotland this was tried in the first UK randomised trial; patients stayed longer in treatment and there was no dramatic escalation in heroin use.

STUDY 2014 HTM file
Treatment retention, drug use and social functioning outcomes in those receiving 3 months versus 1 month of supervised opioid maintenance treatment. Results from the Super C randomized controlled trial

A randomised trial conducted in England found that the (at the time) recommended three months of supervised consumption of prescribed opioid substitutes like methadone conferred no significant advantages over supervising only for up to the first four weeks of treatment, but the findings applied only to the minority of patients for whom random allocation was thought feasible and safe.

STUDY 2010 HTM file
Long-term outcomes of office-based buprenorphine/naloxone maintenance therapy

Abstinence and recovery characterised by employment are priority UK policy objectives to which the extension of mutual aid is considered a major route. This US study illustrates that both the route and the objectives are not just compatible with, but may be promoted by opiate maintenance prescribing.

STUDY 2010 HTM file
Is heroin-assisted treatment effective for patients with no previous maintenance treatment? Results from a German randomised controlled trial

Uniquely among modern heroin prescribing trials, the trial in Germany was not confined to heroin-addicted patients who had done poorly on methadone, offering the opportunity to assess whether heroin should be reserved for these patients. The conclusion was that other patients too benefit more from injectable heroin than oral methadone.

STUDY 2010 HTM file
The Andalusian trial on heroin-assisted treatment: a 2 year follow-up

Heroin/cocaine addicts in Granada in Spain who were being prescribed heroin made greater sustained improvements in their illicit heroin use, crime and psychological health and showed signs of more social reintegration than patients who nearly three years before had been randomly allocated to methadone.

STUDY 2010 HTM file
Effects of psychiatric comorbidity on treatment outcome in patients undergoing diamorphine or methadone maintenance treatment

In Germany, heroin-addicted patients suffering from mental disorders benefited more from being prescribed heroin than methadone and did so to almost the same degree as other patients, including greater remission in psychiatric symptoms.

REVIEW 2012 HTM file
New heroin-assisted treatment: Recent evidence and current practices of supervised injectable heroin treatment in Europe and beyond

Prescribing oral methadone to heroin addicts divides opinions, but prescribing injectable heroin elevates the controversy to another level. Fortunately we now have six randomised clinical trials involving over 1500 patients to ground us in the evidence – and this European Union review to pull it all together.

STUDY 2010 HTM file
Challenges to antagonist blockade during sustained-release naltrexone treatment

Despite being motivated to sustain abstinence and implanted with a drug which should have blocked the effects of opiates, in Norwegian studies most opiate-dependent patients used opiates and about a quarter did so repeatedly.

STUDY 2011 HTM file
A randomized trial of clozapine versus other antipsychotics for cannabis use disorder in patients with schizophrenia

Heavy cannabis use is particularly troubling in patients already struggling with schizophrenia. This study provides the first evidence from a randomised controlled trial that switching such patients to the antipsychotic clozapine may help reduce their cannabis use, but is this worth the extra risk of clozapine compared to the alternatives?


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