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You have found 129 entries after clicking the GO button or a search link in a hot topic. Sorted by the main topic addressed, the list shows in orange the type of entry, year the original document was published (or if one of our own documents, the year last updated), and the type of file you will download when you click on the title. In blue is the document’s title followed by a brief description.

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STUDY 2010 HTM file
A double-blind, placebo-controlled trial combining sertraline and naltrexone for treating co-occurring depression and alcohol dependence

First evidence that combining sertraline for depression with naltrexone for drinking is more effective than either medication alone when dependent drinking is complicated by clinical depression.

REVIEW 2015 HTM file
Risks and benefits of nalmefene in the treatment of adult alcohol dependence: a systematic literature review and meta-analysis of published and unpublished double-blind randomized controlled trials

‘A pill for every ill’ is the gist of the attacks levelled at nalmefene in the form of Selincro, a drug expected to extend the benefits of pharmacotherapy to drinkers not physically dependent or in need of detoxification – or for critics, to medicalise psychosocial dependence on shaky scientific grounds.

REVIEW 2016 HTM file
Antipsychotic medications for cocaine dependence

Search for antipsychotic drugs to treat cocaine dependence has reached a dead end pronounces authoritative review. Psychosocial therapies remain the mainstay of treatment.

STUDY 2015 HTM file
High-dose baclofen for the treatment of alcohol dependence (BACLAD study): A randomized, placebo-controlled trial

From Germany the first trial to rigorously test high doses of the muscle-relaxant baclofen for the treatment of dependent drinking found post-detoxification drinking reductions of a magnitude rarely seen. Other trials have been less positive, and serious safety concerns may limit the drug’s use.

REVIEW 2018 HTM file
Baclofen: its effectiveness in reducing harmful drinking, craving, and negative mood. A meta-analysis

With patchy evidence of the effectiveness of baclofen, and serious concerns about the medication’s safety, is it ‘premature’ for the muscle-relaxant to be prescribed as a treatment for alcohol use disorders?

REVIEW 2012 HTM file
BAP updated guidelines: evidence-based guidelines for the pharmacological management of substance abuse, harmful use, addiction and comorbidity: recommendations from BAP

Practitioner-friendly review from the British Association for Psychopharmacology on drug-based treatments for substance dependence offer authoritative, evidence-based guidance to prescribers and others; they also demonstrate the limitations of trying to cure over-use of drugs with drugs.

DOCUMENT 2017 HTM file
Drug misuse and dependence: UK guidelines on clinical management

Last published in 2007, there is no more important document for UK clinicians involved in treating problem drug use than the so-called ‘Orange guidelines’. This major update offers detailed guidance on the range of problems, settings and patients clinicians encounter, substantially informing judgements of what constitutes good medical practice.

MATRIX CELL 2018 HTM file
Drug Treatment Matrix cell A3: Interventions; Medical treatment

Key studies on the effectiveness of medical interventions and treatment in medical settings.

REVIEW 2005 PDF file 826Kb
Self help: don't leave it to the patients

Keith Humphreys and colleagues report on a workgroup of US experts on substance abuse self-help organisations. Main conclusion: self-help groups are too valuable to leave to chance. They should be actively promoted and facilitated by treatment services and policymakers.

REVIEW 2019 HTM file
The efficacy of spiritual/religious interventions for substance use problems: a systematic review and meta-analysis of randomized controlled trials

Around the world, programmes which take a spiritual or overtly religious route to overcoming substance use problems are extremely common and in some countries dominant – but do they work any better than the alternatives? This review systematically sifted the evidence from the past 30 years.


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