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You have found 446 entries after clicking on a search link (usually the MORE information link) in a matrix cell. Sorted by the main topic addressed, the list shows in orange the type of entry, year the original document was published (or if one of our own documents, the year last updated), and the type of file you will download when you click on the title. In blue is the document’s title followed by a brief description.
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STUDY 2009 HTM file
Explaining the effectiveness of heroin-assisted treatment on crime reductions
This German study shows that heroin maintenance treatment can contribute to greater reductions in drug and property offences than methadone maintenance.
REVIEW 2015 HTM file
Heroin on trial: systematic review and meta-analysis of randomised trials of diamorphine-prescribing as treatment for refractory heroin addiction
The UK has a long history of prescribing heroin for the treatment of heroin dependence. What has research from six countries concluded about this intensive intervention intended for patients who would otherwise be considered ‘unresponsive’ to treatment?
STUDY 2012 HTM file
After the randomised injectable opiate treatment trial: post-trial investigation of slow-release oral morphine as an alternative opiate maintenance medication
Slow-release capsules of morphine – the closest drug to heroin – might offer acceptable and effective treatment to addicts who cannot settle on methadone. In England a dozen also being prescribed heroin switched their supplementary methadone to morphine, generally experiencing the benefits they expected and cutting their average dose of heroin.
STUDY 2006 PDF file 108Kb
1 in a 100 chance of dying after treatment with heroin-blocking drug
In Australia heroin-addicted patients trying to avoid relapse by taking the opiate-blocking drug naltrexone had at least a 1 in a 100 chance of dying within three months, usually from overdose in the weeks after treatment ended; the true figure may have been as high as 8 in a 100.
STUDY 2010 HTM file
Naltrexone implants compared to methadone: outcomes six months after prison release
In the first study of its kind opiate-dependent prisoners in Norway were randomly allocated to a six-month implant which blocks the effects of heroin or to methadone which substitutes for heroin as a way of bridging the period after release. Among the few interested in either option, they led to equivalent reductions in opiate use and crime.
STUDY 2010 HTM file
Treatment research in prison: problems and solutions in a randomized trial
In the first study of its kind, as a way of bridging the period after release opiate-dependent prisoners in Norway were randomly allocated to a six-month implant which blocks the effects of heroin or to methadone which substitutes for heroin. Many prisoners rejected treatment, wrongly believing they would sustain abstinence on release.
STUDY 2011 HTM file
Injectable extended-release naltrexone for opioid dependence: a double-blind, placebo-controlled, multicentre randomised trial
In Russia, injecting detoxified opiate addicts with long-acting naltrexone which blocks opiates for a month meant more were able to stay off the drugs, findings which helped persuade US authorities to approve it for this role. Others argue this was precipitate given the lack of evidence on overdose protection.
HOT TOPIC 2018 HTM file
Opiate-blocking implants: magic bullet or dangerous experiment?
‘Hot topics’ offer background and analysis on important issues which sometimes generate heated debate. Opinion is sharply divided on the ethics and effectiveness of long-acting implanted or injected opiate-blocking medications, products not approved for medical practice in the UK, but which some see as a major breakthroughs in overcoming addiction to heroin and allied drugs.
DOCUMENT 2012 HTM file
An introduction to extended-release injectable naltrexone for the treatment of people with opioid dependence
Few treatments arouse as much controversy as long-acting naltrexone implants or injections which promise to block the effects of heroin for up to several months. But in the USA the injected form has been licensed for treating opioid dependence. This document offers official US clinical guidance to doctors undertaking the treatment.
STUDY 2015 HTM file
Opioid treatment at release from jail using extended-release naltrexone: a pilot proof-of-concept randomized effectiveness trial
Though few seemed willing to try this treatment, among those who did, opiate-blocking injections active for about a month helped formerly dependent prisoners in New York City’s jail avoid relapse to regular opiate use after release.
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