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STUDY 1992 HTM file
Disulfiram treatment of alcoholism
Still relevant today, from the early 1990s a UK randomised trial of disulfiram in the treatment of alcohol dependence found that it significantly reduced drinking when there was daily supervision to make sure patients took the tablets, and they knew these would cause unpleasant physical effects if they drank.
STUDY 2001 PDF file 99Kb
Naltrexone prevents return to heavy drinking
The British study which provided the largest test to date of naltrexone in the treatment of alcohol dependence. In conditions typical of NHS alcohol treatment centres, it confirmed that taken as directed, the drug reduces alcohol consumption.
STUDY 2001 PDF file 143Kb
In UK acamprosate fails to prevent relapse to drinking but European evidence remains positive
A large UK trial found that acamprosate failed to reduce relapse among detoxified alcoholics but more positive international evidence was confirmed in Italy. Differences in patients, regimes and measures might account for the difference.
STUDY 2001 PDF file 197Kb
Alcohol dependence typology may help decide which drugs to prescribe
In two US studies drugs with an opposing impact on a key neurotransmitter system helped different types of alcoholics curb their drinking, raising the prospect of being able to match patients to the drug elements of their treatments.
REVIEW 2002 PDF file 174Kb
Convincing evidence that acamprosate and naltrexone help prevent alcohol relapse
Despite patchy results in individual studies, two meta-analyses which combined findings from rigorous trials have confirmed that acamprosate and naltrexone help prevent relapse after detoxification from alcohol. See extended text for further studies.
STUDY 2003 PDF file 188Kb
Naltrexone helps heavy drinkers gain control
In Spain naltrexone helped young regular binge drinkers cut back, potentially extending its role from alcoholics seeking treatment at specialist clinics to problem drinkers identified in other settings such as primary care.
STUDY 2005 PDF file 142Kb
Anti-alcohol drug also reduces cocaine use
US trial shows that when cocaine dependence and heavy drinking are intertwined, prescribing the anti-alcohol medication disulfiram helps resolve both problems, unless patients are so wedded to drink that they stop taking the pills.
STUDY 2005 PDF file 170Kb
'Real-world' studies show that medications do suppress heavy drinking
Three trials found that drugs commonly used to treat alcohol dependence improve outcomes for an appreciable minority of patients, even under conditions close to normal practice. Together they offer clues to who benefits most from each medication.
STUDY 2005 PDF file 112Kb
Pharmacotherapies which work with men do not help women
Emerging indications from studies of disulfiram treatment of cocaine dependence and sertraline for alcohol dependence that pharmacotherapies which work for men do not always help women.
STUDY 2005 PDF file 172Kb
Naltrexone specially helps poor prognosis patients avoid relapse to heavy drinking
Two European studies confirm that the opiate-blocking drug naltrexone particularly helps alcohol-dependent patients who respond least well to therapy (marked partly by early onset drinking problems), elevating in-treatment outcomes to those of more promising clients.
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