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You have found 294 entries after clicking on a search link (usually the MORE information link) in a matrix cell. Sorted by the main topic addressed, the list shows in orange the type of entry, year the original document was published (or if one of our own documents, the year last updated), and the type of file you will download when you click on the title. In blue is the document’s title followed by a brief description.

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REVIEW 2012 HTM file
Acamprosate for alcohol dependence: a sex-specific meta-analysis based on individual patient data

The first comprehensive analysis of whether acamprosate treatment works as well for alcohol-dependent women as for men definitively concludes that across 22 mainly European trials it has had a virtually identical impact. The analysis also reports the drug's overall impact, finding that it helps prevent heavy drinking as well as fostering abstinence.

STUDY 2010 HTM file
Naltrexone and combined behavioral intervention effects on trajectories of drinking in the COMBINE study

Reanalysis of the largest US study of medication-based alcoholism treatment confirms that either naltrexone or psychological therapy improved outcomes more than medical care and placebos, while the two in combination or acamprosate added little. It also revealed previously invisible benefits when certain types of patients received certain treatments.

REVIEW 2015 HTM file
Risks and benefits of nalmefene in the treatment of adult alcohol dependence: a systematic literature review and meta-analysis of published and unpublished double-blind randomized controlled trials

‘A pill for every ill’ is the gist of the attacks levelled at nalmefene in the form of Selincro, a drug expected to extend the benefits of pharmacotherapy to drinkers not physically dependent or in need of detoxification – or for critics, to medicalise psychosocial dependence on shaky scientific grounds.

REVIEW 2013 HTM file
Metaanalysis of naltrexone and acamprosate for treating alcohol use disorders: when are these medications most helpful?

Naltrexone and acamprosate both modestly curtail drinking among alcohol-dependent patients, but which is best in which circumstances and for which treatment goals? To find out this review compared the medications’ performance when separately benchmarked against a placebo, bringing to bear much more data than is available from the few trials which directly compared the two drugs.

STUDY 2015 HTM file
High-dose baclofen for the treatment of alcohol dependence (BACLAD study): A randomized, placebo-controlled trial

From Germany the first trial to rigorously test high doses of the muscle-relaxant baclofen for the treatment of dependent drinking found post-detoxification drinking reductions of a magnitude rarely seen. Other trials have been less positive, and serious safety concerns may limit the drug’s use.

REVIEW 2018 HTM file
Baclofen: its effectiveness in reducing harmful drinking, craving, and negative mood. A meta-analysis

With patchy evidence of the effectiveness of baclofen, and serious concerns about the medication’s safety, is it ‘premature’ for the muscle-relaxant to be prescribed as a treatment for alcohol use disorders?

REVIEW 2010 HTM file
Acamprosate for alcohol dependence

The first review from the prestigious Cochrane collaboration of the drug acamprosate as a treatment for alcohol dependence finds clear evidence that it offers worthwhile if modest benefits in preventing a return to drinking after detoxification.

REVIEW 2005 PDF file 449Kb
Can we help?

Part 2 of the Manners Matter series explores the neglected parts of service delivery – how to help people get there on time. Transport and childcare are key ingredients but a helping hand does more than help carry the load; it shows that you care.

STUDY 1999 PDF file 209Kb
Advice and referral curb drinking in alcohol dependent hospital patients

In New York the serendipitous misapplication of a brief intervention to alcohol-dependent general hospital patients raised the possibility that they benefit as much from this as from referral to full-blown treatment.

STUDY 2000 PDF file 115Kb
Brief intervention leaves teenage drinkers less likely to revisit accident and emergency

A brief intervention intended to reducing harmful/risky drinking and tested on teenagers attending a US emergency unit after an alcohol-related incident substantially cut the number of alcohol-related injuries over the next six months.


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