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You have found 134 entries after clicking the GO button or a search link in a hot topic. Starting with the most recently added or updated entries, the list shows in orange the type of entry, year the original document was published (or if one of our own documents, the year last updated), and the type of file you will download when you click on the title. In blue is the document’s title followed by a brief description.

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STUDY 2019 HTM file
Criminal justice outcomes over 5 years after randomization to buprenorphine-naloxone or methadone treatment for opioid use disorder

Can a limited period of being prescribed opiate-type medications generate longer term reductions in the criminal behaviour of patients dependent on illegal opiates like heroin? And of the two main medications – buprenorphine and methadone – which performs best? It seems a key factor is how well they retain patients in treatment.

REVIEW 2018 HTM file
A review of brain stimulation methods to treat substance use disorders

Already used to treat various neurological and psychiatric disorders, a review investigates the utility of brain stimulation techniques for drug and alcohol problems.

STUDY 2019 HTM file
Efficacy and cost-effectiveness of an adjunctive personalised psychosocial intervention in treatment-resistant maintenance opioid agonist therapy: a pragmatic, open-label, randomised controlled trial

Instead of a set programme, a clinic in London tried offering methadone or buprenorphine patients still using heroin or cocaine a selection from a suite of well-supported psychological interventions tailored to the patient and then systematically re-tailored in the light of how they responded. It worked – but did it work well enough, and would the findings be replicated in more typical circumstances?

STUDY 2015 HTM file
A double blind, placebo controlled trial of modafinil for the treatment of cocaine dependence without co-morbid alcohol dependence

Modafinil is a mild stimulant which it is hoped might plug the gap in effective pharmacotherapies for dependence on cocaine. Though this trial found that it promoted abstinence from cocaine, others have not, and its inconsistent benefits have been seen as failing to outweigh the drug’s side effects.

REVIEW 2016 HTM file
How can contingency management support treatment for substance use disorders? A systematic review

Rewarding people dependent on illegal drugs for not using those drugs is a controversial tactic, one this review from the EU’s drug misuse centre found patchily effective in extending retention and reducing substance use as a supplement to medication-based treatments.

STUDY 2018 HTM file
Adult substance misuse statistics from the National Drug Treatment Monitoring System (NDTMS) 1 April 2016 to 31 March 2017

The annual accounting of the treatment caseload in England registers a continuing fall in total numbers and decreasing success with opiate users, while success with drinkers has increased and has for the last few years remained relatively high and stable. An ageing population of opiate users is the proposed explanation for the former trend – but why hasn’t a similarly ageing alcohol caseload also eroded success rates?

DOCUMENT 2007 HTM file
Drug misuse in over 16s: psychosocial interventions

After examining the evidence for psychosocial therapies for problem drug use, the UK’s official health advisers recommend behavioural couples therapy and contingency management, argue against cognitive-behavioural therapies, and pose residential rehabilitation as a last resort – in some respects surprising and controversial recommendations.

REVIEW 2016 HTM file
Psychosocial interventions for psychostimulant misuse (Review)

A review revealing contingency management may be a promising treatment option for problem cocaine and amphetamine use, but unable to answer the big question – ‘is one psychosocial approach more effective than the others and in what circumstances?’

HOT TOPIC 2017 HTM file
The ‘explosion’ that never happened; crack and cocaine use in Britain

One of our hot topics – essays on important issues which sometimes generate heated debate. In 1989 a whirlwind of concern was stirred up by a US drug enforcement officer who foresaw a US-style “explosion” of violence associated with the ‘almost instantly addictive’ crack version of cocaine in Britain. That did not happen – but what did, where do those claims stand today, and what of cocaine powder, for decades seen as the ‘champagne set’s’ favourite drug?

STUDY 2014 HTM file
For whom does prison-based drug treatment work? Results from a randomized experiment

For the first time in a prison setting a randomised trial rigorously compared intensive residential therapeutic community treatment to outpatient counselling. Confounding expectations, the US prison for problem drug users which hosted the study gained nothing in terms of preventing recidivism by allocating even high-risk prisoners to the more intensive treatment.


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