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You have found 49 entries after clicking on a search link (usually the MORE information link) in a matrix cell. Sorted by the main topic addressed, the list shows in orange the type of entry, year the original document was published (or if one of our own documents, the year last updated), and the type of file you will download when you click on the title. In blue is the document’s title followed by a brief description.

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STUDY 2011 HTM file
A good quality of life under the influence of methadone: a qualitative study among opiate-dependent individuals

Opiate dependent methadone patients in Belgium give their own accounts of what for them constitutes a good quality of life. Generally they want what other people want: a meaningful, independent life and supportive relationships. Methadone creates the preconditions for such a life at the same time as it limits its achievement.

STUDY 2012 HTM file
Randomized trial of standard methadone treatment compared to initiating methadone without counseling: 12-month findings

Up to a year after starting methadone treatment US patients offered virtually no counselling for the first four months were still doing as well as those offered regular counselling. But there is a hint that intensive and high quality counselling enabled more to safely leave treatment.

STUDY 2008 HTM file
Does following research-derived practice guidelines improve opiate-dependent patients’ outcomes under everyday practice conditions? Results of the Multisite Opiate Substitution Treatment study

In everyday practice at methadone maintenance clinics and with the full range of patients, does implementing clinical guidelines lead to better outcomes for patients? Two sets of US clinics selected for high versus low adherence to guidelines provided evidence that the recommended high doses and intensive psychosocial services really do make the intended difference.

DOCUMENT 2017 HTM file
Drug misuse and dependence: UK guidelines on clinical management

Last published in 2007, there is no more important document for UK clinicians involved in treating problem drug use than the so-called ‘Orange guidelines’. This major update offers detailed guidance on the range of problems, settings and patients clinicians encounter, substantially informing judgements of what constitutes good medical practice.

STUDY 2000 PDF file 148Kb
English residential rehabilitation services doing well but could do better

A report from the UK National Treatment Outcome Research Study (NTORS) spotlights the achievements of residential services for drug users but more could be done to improve retention and it is unclear how much the treatment had to do with the outcomes.

STUDY 2001 PDF file 140Kb
Brief interventions help cannabis users cut down

Studies from Australia and the USA show that heavy, long-term cannabis users can be attracted into brief interventions which reduce consumption and improve quality of life and health prospects. For most, longer interventions are unnecessary.

STUDY 2011 HTM file
Shared decision-making: increases autonomy in substance-dependent patients

An innovative Dutch study tested a way of involving substance users as equals in decisions over issues addressed in their treatment. The effect was to give these typically submissive personalities a greater sense of control over their lives. Just as influential was the lead offered by the clinician's personality.

STUDY 2010 HTM file
Effect of motivational interviewing on reduction of alcohol use

At Californian methadone clinics, group education sessions led by a nurse and focused on the risks of aggravating hepatitis infection led to the same substantial reductions in drinking as one-to-one or group motivational interviewing conducted by highly trained counsellors, offering a cost-effective means to reduce alcohol-related risks.

STUDY 2019 HTM file
Efficacy and cost-effectiveness of an adjunctive personalised psychosocial intervention in treatment-resistant maintenance opioid agonist therapy: a pragmatic, open-label, randomised controlled trial

Instead of a set programme, a clinic in London tried offering methadone or buprenorphine patients still using heroin or cocaine a selection from a suite of well-supported psychological interventions tailored to the patient and then systematically re-tailored in the light of how they responded. It worked – but did it work well enough, and would the findings be replicated in more typical circumstances?

STUDY 1999 PDF file 223Kb
Treatment staff matter as much as the drug

Three US studies prove there is more to methadone maintenance than the drug. The individual counsellor and whether they respond constructively to patient problems can dramatically affect retention and drug use outcomes.


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